TOXNET: Toxicology Data Network
Data NETwork) is a cluster of databases covering toxicology,
hazardous chemicals, environmental health and related areas. It
is managed by the Toxicology
and Environmental Health Information Program (TEHIP) in the
Division of Specialized
Information Services (SIS) of the National Library of Medicine (NLM).
TOXNET provides free access to and easy searching of the
(Hazardous Substances Data Bank)
- A factual database focusing on the toxicology of over 4,800
potentially hazardous chemicals. In addition to toxicity data,
HSDB provides information in the areas of emergency handling
procedures, industrial hygiene, environmental fate, human
exposure, detection methods, and regulatory requirements. The
data are fully referenced and peer-reviewed by a Scientific
Review Panel composed of expert scientists.
(Integrated Risk Information System)
- A database from the U.S.
Environmental Protection Agency (EPA) containing carcinogenic
and non-carcinogenic health risk information on over 500
chemicals. IRIS risk assessment data has been scientifically
reviewed by EPA scientists and represents EPA consensus.
(International Toxicity Estimates for Risk)
- This database contains data in support of human health risk
assessments. It is compiled by Toxicology Excellence for Risk
Assessment (TERA) and contains over 600 chemical records.
ITER provides a comparison of international risk assessment
information in a side-by-side format and explains differences in
risk values derived by different organizations. ITER data,
focusing on hazard identification and dose-response assessment,
is extracted from each agency’s assessment and contains
links to the source documentation.
(Chemical Carcinogenesis Research Information System).
- A scientifically evaluated and fully referenced data bank,
developed and maintained by the National Cancer Institute (NCI). It
contains over 8,900 chemical records with carcinogenicity,
mutagenicity, tumor promotion, and tumor inhibition test results.
Data are derived from studies cited in primary journals, current
awareness tools, NCI reports, and other special sources. Test
results have been reviewed by experts in carcinogenesis and
- A toxicology database created by the U.S. Environmental
Protection Agency (EPA) containing genetic toxicology test
results on over 3,000 chemicals. Selected literature was reviewed
by scientific experts for each of the test systems under
evaluation; the results are represented in GENE-TOX.
- Tox Town
- An interactive guide to commonly encountered toxic
substances, your health, and the environment. It uses color,
graphics, sounds and animation to convey connections between
chemicals, the environment, and the public's health. The City or
Town neighborhoods are designed to provide facts on toxic
chemicals found in everyday locations, information about how the
environment can impact human health, non-technical descriptions
of chemicals, links to authoritative chemical information on the
Internet, and Internet resources on environmental health topics.
Tox Town's target audience is students above elementary-school
level, educators, and the general public. It is a companion to
the extensive information in the TOXNET collection of databases
that are typically used by toxicologists and health
professionals. Tox Town also offers some resources in Spanish
- Household Products
- This database provides information on the potential health
effects of chemicals contained in more than 4,000 common
household products used inside and around the home. The database
allows users to browse a product category, such as 'Pesticides'
or 'Personal Care,' by alphabetical listing of brand names.
Products can also be searched by type, manufacturer, product
ingredient/chemical name and by health effects. The record for
each product shows the ingredients as reported in the
manufacturer's Material Safety Data Sheet (MSDS) and includes
other information such as handling, disposal, and health
- An occupational toxicology database designed primarily for
health and safety professionals, but also for consumers seeking
information about the health effects of exposure to chemicals at
work. It links jobs and hazardous tasks with occupational
diseases and their symptoms. The approximately 1,000 chemicals
and biological agents in the database are related to industrial
processes and other activities such as hobbies. The linkage
indicates the potential for exposure to the agents. The 180
occupational diseases and their symptoms are associated with
hazardous job tasks. This association indicates an increased risk
for significant exposure and subsequent disease.
- A web site from the National Library of Medicine (NLM) that
uses maps of the United States to show the amount and location of
toxic chemicals released into the environment. Data is derived
from the EPA's Toxics Release Inventory (TRI), which provides information on
the releases of toxic chemicals into the environment as reported
annually by industrial facilities around the United States.
The TOXNET "Multiple Databases" option allows for simultaneous
searching of HSDB, IRIS, CCRIS, and GENE-TOX.
- A bibliographic database providing comprehensive coverage of
the biochemical, pharmacological, physiological, and
toxicological effects of drugs and other chemicals from 1965 to
the present. TOXLINE contains over 3 million citations, almost
all with abstracts and/or index terms and CAS Registry Numbers.
TOXLINE references are drawn from sources grouped into two major
Core and TOXLINE
Special, both of which offer a variety of search and display
(Development and Reproductive Toxicology/Environmental Teratology
- A bibliographic database covering literature on reproductive
and developmental toxicology. DART is managed by NLM and funded
by the EPA, the National
Institute of Environmental Health Sciences (NIEHS) and NLM.
DART/ETIC contains references to reproductive and developmental
toxicology literature published since 1965.
- Toxics Release
- A series of databases that describe the releases of toxic
chemicals into the environment annually for the 1987-2002
reporting years. TRI is mandated by the Emergency Planning and
Community Right-to-Know Act and is based on data submitted to the
EPA from industrial facilities throughout the U.S. These data
include the names and addresses of those facilities, and the
amounts of certain toxic chemicals they release to the air,
water, or land, or transfer to waste sites. Information is
included on over 650 chemicals and chemical categories. Pollution
prevention data are also reported by each facility for each
- A database providing access to structure and nomenclature
authority databases used for the identification of chemical
substances cited in NLM databases. ChemIDplus contains over
368,000 chemical records, of which over 235,000 include chemical
structures. ChemIDplus is searchable by Name, Synonym, CAS
Registry Number, Molecular Formula, Classification Code, Locator
Code, and Structure. A new ChemIDplus Lite
version is available for Name and RN searching without the need
for plugins or applets.
- A database of over 213,000 substances with 2D and 3D
information compiled from the National Cancer Institute
TOXNET databases are accessible free of charge at: //toxnet.nlm.nih.gov
TOXNET's web interface is designed as an easy way to search
databases of varying formats and content. It can be used to
locate toxicology data, literature references, and toxic release
information on particular chemicals as well as to search to
identify chemicals that cause specific effects. TOXNET offers a
variety of ways to display and sort information. Its
"Multi-Databases" feature provides an integrated search of any or
all of several databases (HSDB, IRIS, CCRIS, GENE-TOX). Its
"Search All Databases" feature provides a list of TOXNET
databases in which a search term is found, each paired with the
retrieval record count and with links to the Search Results page
of those databases.
Links are available from TOXNET to PubMed(R), NLM's free web
interface to the world's biomedical literature, and to additional
sources of toxicological information.
For detailed information on TOXNET, contact:
Specialized Information Services
National Library of Medicine
Two Democracy Plaza, Suite 510
6707 Democracy Boulevard, MSC 5467
Bethesda, MD 20892-5467
Telephone: (301) 496-1131
For general information on the Library's computerized
information services, including TOXNET, contact:
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Telephone: 1-888-FINDNLM (1-888-346-3656)
A complete list of NLM Fact Sheets is available
(alphabetical list) //www.nlm.nih.gov/pubs/factsheets/factsheets.html
(subject list): //www.nlm.nih.gov/pubs/factsheets/factsubj.html
Or write to:
Office of Communications and Public Liaison
National Library of Medicine
8600 Rockville Pike
Bethesda, Maryland 20894
Phone: (301) 496-6308
Fax: (301) 496-4450
Certisafety Section Home Page